From Charlotte

Take U.S. 74 East toward Monroe. Turn right onto U.S. 601 South. Continue onto S.C. 151 South. Stay on S.C. 151 for about 50 miles, and you will arrive in Darlington.

From Myrtle Beach

Take U.S. 501 North through Conway. Take a slight left onto S.C. 576 near Marion, and then continue onto U.S. 76 West. Take a right onto S.C. 327 North to I-95. Take I-95 South to Exit 164. Turn right off the interstate onto U.S. 52 toward Darlington. In about 10 minutes, you will arrive downtown.

From I-95

Take Exit 164 onto U.S. 52 toward Darlington. In about 10 minutes, you will arrive downtown.